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In bladder cancer cells, the combination of triptolide and hydroxycamptothecin significantly enhances G0/G1 phase arrest by inhibiting CDK4, CDK6, and Cyclin D1

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Raw broad beans also contain the alkaloids vicine and convicine which can induce hemolytic anemia in patients with the hereditary condition glucose-6-phosphate dehydrogenase deficiency

[DOI] [PubMed] [Google Scholar] 64.Jaroudi S., Kakourou G., Cawood S., Doshi A., Ranieri D.M., Serhal P., Harper J.C., SenGupta S.B

Mitosis-associated kinases In addition to targeting microtubules and targeting DNA damage, as described above, another highly important strategy is targeting mitosis-associated kinases