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Increased intestinal translocation of immunogenic agents, including microbes and dietary components, induces inflammation and increases the risk of developing autoimmunity or other non-infectious diseases (Table 2)

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Potency and PK anchors: Lau 2015 (cAMP EC50 6.2 pmol/L), Boianelli 2024 (free fraction 0.36%), FDA 2021 (weight-change EC50 54.6 nmol/L)

10.1016/J.FEBSLET.2009.10.069 [DOI] [PubMed] [Google Scholar] Hsu CH, Liu CY, Lo KY (2024) Mutations of ribosomal protein genes induce overexpression of catalase in Saccharomyces cerevisiae

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Generic product-line COAs that do not reference a specific lot are insufficient