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It should be noted that when combination products were used, some observed effects may reflect contributions from other components and not solely BBR

However, platelets from this patient clearly expressed very low NBEAL2 levels (Figure 3A,B)

This trend was also observable for polyhexanide and NAC, although differences were less marked

Shibata T, Uryu S, Kokubu A, Hosoda F, Ohki M, Sakiyama T, Matsuno Y, Tsuchiya R, Kanai Y, Kondo T, et al

Cannabinoid receptor 2: potential role in immunomodulation and neuroinflammation

In IC, TGF- fails to effectively mediate tissue regeneration, leading to fibroblast activation and fibrosis, which further inhibits cell proliferation (Mormone et al., 2024)