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Targeting microenvironment-mediated resistance in leukemias: Phase I trial of mobilization and elimination of FLT3-ITD+ acute myelogenous leukemia (AML) stem/progenitor cells by plerixafor/g-CSF/sorafenib

The development of a biomimetic scaffold comprises different aspects, such as the fabrication technique, which determines the macro- and microarchitecture of the scaffold, the material used for scaffold fabrication and the inclusion within the scaffold of bioactive molecules or other stimulating factors to promote the formation of a functional tissue (Figure 1)

[9] Meredith ME, Salameh TS, Banks WA

PMID: 38640835, PMCID: PMC11041015, DOI: 10.1016/j.ebiom.2024.105114

The CASTA Failure: The 2012 CASTA triala large, multicenter, double-blind study of Cerebrolysin for acute ischemic stroke in Asia (n=1,070)failed to meet its primary endpoint, showing no significant benefit over placebo

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