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Tumor-specific down-regulation of the tumor necrosis factor-related apoptosis-inducing ligand decoy receptors DcR1 and DcR2 is associated with dense promoter hypermethylation

In human HCC cell lines, knockdown of HMGCS2 increases tumor growth and cell migration, while HMGCS2 overexpression decreases cell proliferation and increases apoptosis (Wang et al., 2019b

Endocrinology 148 , 24582464 (2007)

There is presently no way to reverse such outcomes

Genetic associations with apolipoprotein B were obtained from UK Biobank

[DOI] [PMC free article] [PubMed] [Google Scholar] 143.Nguyen TD, Shingu Y, Amorim PA, Schwarzer M, Doenst T