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Figure 2 On the other hand, it has been reported that activated PKA can limit the levels of cAMP by either the stimulation of phosphodiesterases (PDE) ( Figure 2 ), or through the desensitization of some GPCRs (36, 4042)

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Half-Life ~78 days Injection Subcutaneous Frequency Once weekly Storage 2 8 C Titration Schedule Standard dose escalation from 0.25 mg to the 2.4 mg maintenance dose over 16 weeks

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