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No IGF-1 elevation

The vial format supports precise dose-response studies in cell-culture and animal models of NNMT inhibition and adipose-tissue metabolic regulation

Higher doses may increase gastrointestinal side effects without improving outcomes

Here are two of the most notable experiments to date: In an 11-day study, obese mice treated with 20mg/kg of 5-amino-1MQ trice daily experienced a 5.1% weight reduction from baseline, while control mice gained 1.4% in body weight

Additionally, Parasutterella relative abundance, which was increased in both the vehicle- and NNMTi-treated LD-switched groups relative to the controls, significantly correlated with several adipose tissue metabolites abundances

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