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This inefficient process produces excessive lactic acid, alters cellular pH, and causes microscopic muscle damage that can take days or weeks to repair

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(2012), 9cRA was repeatedly administered through the intra-nasal route as intracerebral delivery is not feasible for repeated drug administration and may require chronic cannulation, whereas small molecules bypass the bloodbrain barrier and reach brain parenchyma non-invasively if delivered via the intranasal route

10.1007/s40122-017-0091-4 Pain Ther

A transport protein is needed to take up carnitine against this gradient and this transport is the limiting factor

doi: 10.1186/s13195-018-0451-2 68 WandersR