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Moreover, the oral administration of dexamethasone (20 mg) prior to and during surgical of mandibular third molars extraction may considerably reduce trismus and increase mouth opening [12]

Post-Market Surveillance Gap: Because AOD-9604 never received FDA approval for any indication, there is no post-market surveillance system capturing safety signals from widespread clinical use
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A study published in Endocrinology demonstrated that chronic treatment with the fragment in obese mice resulted in a reduction of adipose tissue mass without changes in lean body mass or food consumption

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