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Transmembrane proteins of the tight junctions at the blood-brain barrier: structural and functional aspects

Mature T cells leave the thymus and migrate to secondary lymphoid organs, where they monitor peptide fragments presented by MHC molecules on APC surfaces [85]

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In mammalian cells, it triggers mitochondrial membrane disruption and cytochrome C release, subsequently inducing cell apoptosis 49,50

However, they stress, that despite their advantages, natural antimicrobial peptides are not a panacea and have many inherent limitations, including high production costs, unstable activity, protease and pH sensitivity, and incomplete toxicological safety data [47]