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A study of 10,000 consecutive male donors in a New York City hospital blood bank demonstrated that 13% of donors of African descent were G6PD-deficient versus a frequency of 0.9% in Caucasian donors.[53] We recently found that the frequency of G6PD deficiency among random RBC units in a metropolitan transfusion service (0.3%) was significantly lower than that of units used for exchange transfusions for SCD patients receiving Rh-positive units that were negative for the C and E antigens (12.3%).[10] Thus, with the growing popularity of programs that provide phenotypically-matched RBCs for SCD patients, the possibility of receiving a G6PD-deficient unit may be higher for these patients

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