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Collectively, these findings suggest that the circadian clock acts as an anti-inflammatory rheostat, and its misalignment can amplify immune-mediated injury in both the kidney and the eye

As outlined in the Figure above the pathway of melatonin synthesis from serotonin involves two reactions

We performed RNA sequencing (RNA-seq) on the fractionated adipocytes from the gWAT of these mice

Criscione, S