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Introduction Chronic pain and depression are leading causes of disability that are frequently encountered comorbidly in a variety of clinical conditions, sharing genetic and psychological risk factors, a relapsing-chronic course, and neurobiological features (Meyer et al., 2007
& Cunningham, C
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These microbial shifts coincide with elevated SCFA levels and increased expression of UCP1, CPT1B, and SIRT1 in adipose depots, indicating that AX promotes thermogenesis through a gut microbiotametaboliteUCP1 regulatory axis that integrates intestinal and systemic energy homeostasis [73,75,76]
[DOI] [PMC free article] [PubMed] [Google Scholar] Wiggins WF, Graef JD, Huitt TW, et al
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