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Treatment with RSV prevents all the pathologic changes in the brains of experimental animals triggered by VPA [67]

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The above change is associated with long-lasting decreases in the expression of the glial glutamate transporter 1 (GLT-1) and the cystine-glutamate exchange system/antiporter (system x c ) within the nucleus accumbens and/or prefrontal cortex related to downregulation of the genes encoding the latter system [6,7,8,9,10,11]

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