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After 96 weeks, the primary outcome, defined as the rate of improvement in NASH, was assessed against the placebo and the vitamin E group (800 IU/day) showed a statistically significant improvement (34%) while the pioglitazone group (30 mg/day) failed to demonstrate a significant improvement [35]

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In fact, in the compromised scenario of cholestasis, an inflammatory process is established, with a concomitant increase in levels of acute-phase proteins (APP) like serum TNF- and biliary phospholipase A2, resulting in a further increase in oxidative stress highlighted by raised levels of MDA in the bile [176]

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62 KaaksR.JohnsonT.TikkK.SookthaiD.TjnnelandA.RoswallN.et al (2014)