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Using preterm pigs as a model, we observed that systemic injection of IGF-1 stimulated brain protein synthesis and promoted gray matter and white matter maturation in a spatiotemporal manner, but did not affect brain weight or motor skills in the early perinatal period

The activation of VEGFR-1 leads to inflammation, while the activation of VEGFR-2 leads to angiogenesis (Farghaly et al., 2021)

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PubMed References are provided for scientific background only

The successful construction was confirmed by PCR using appropriate primers (Table S3), followed by sequencing of the PCR products

Sacrifice was achieved under anesthesia (3% isoflurane at 0.5 L/min of O 2 ) after a 4 h fast to standardize the feeding status of each animal