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[,] In an in vitro experiment using TRAMP C1 cells, SFN was found to cause epigenetic modifications in the expression of several HDAC proteins, thereby restoring Nrf-2 expression

Pure Appl Chem

Xiang and Oliver 1999)

Why this trial matters : First oral SERD to succeed in Phase III in early breast cancer Signals a potential new adjuvant standard of care Advances endocrine therapy beyond legacy agents Johnson & Johnson Tecvayli + Darzalex Faspro Shows Unprecedented Phase III Success in Relapsed/Refractory Multiple Myeloma The Phase III MajesTEC-3 trial demonstrated that the combination of Tecvayli (teclistamab) plus Darzalex Faspro (daratumumab SC) significantly improved progression-free survival and overall survival versus standard regimens in patients with relapsed/refractory multiple myeloma as early as second-line, with an ~83% reduction in disease progression or death at almost three years follow-up

Open Forum Infect Dis (2021) 8(6):ofab109

10.1038/s41419-020-2365-8 151 LeeS