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doi: 10.5021/ad.2021.33.5.474 29 JungJMLeeYJWonCHChangSELeeMWChoiJHet al

Double-stranded breaks create unique risks to cells, and base editing, when only small changes are needed, may be a safer alternative to conventional CRISPR-based editing

This finding highlights the important role of amino acid recycling by the 26S proteasome in cellular survival, although it remains unclear how free amino acid content affects cellular physiology