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We found that the inflammatory factors, Il-1, Il-6, Cxcl15 , and Tnf- , which are related to aging, were significantly decreased in the aging-related secretory phenotype (Figure 1B)

J Diabetes 2019;11:729-43

If it doesnt move the needle within 2 weeks (at a push 4 weeks), we change and try again

Fourman, L., Billingsley, J., Agyapong, G., Sui, S., Feldpausch, M., Purdy, J., Zheng, I., Pan, C., Corey, K., Torriani, M., Kleiner, D., Hadigan, C., Stanley, T., Chung, R., & Grinspoon, S

While these approaches remain important, a growing body of scientific research suggests that autism may also involve deeper biological mechanisms including mitochondrial dysfunction, chronic neuroinflammation, immune imbalance, and disruption of the gutbrain axis

these factors make GLP-1 RAs an alternative initial treatment option, with or without metformin based on glycemic needs, in T2DM patients with indicators of high-risk or established heart failure (HF) or CKD who cannot tolerate an SGLT2 inhibitor
