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Stpnicki P, Kondej M, Kaczor AA

We further assessed the association between the expression of genes regulating glyoxylate metabolism or oxalate formation and MASH through regression models and a meta-analysis based on transcriptomics of livers from patients with or without MASH (GSE83452 and GSE61260) 30,31

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Common regulatory pathways in both ferroptosis and autophagy Even though strong links exist between ferroptosis and autophagy, the relationship between them is more than a simple positive or negative correlation, different regulatory mechanisms emerge depending on the situation

To test the literature-based model, we systematically adjusted the various reaction rates by numerical optimization of the likelihood function to minimize the discrepancy between the time-course of the observed concentrations in the fluorescent reporter cell lines and the corresponding model predictions