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The tip of the microvilli is always relatively hypoxic compared to the base, and in reduced perfusion states, oxygen will tend to move down a gradient from arteriole to venule closer to the base, thus exacerbating hypoxia at the tip and potentially switching apoptosis to necrosis in epithelial cells

Alamed, J

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Anchor logic: why the two are stacked Think of tissue repair as a construction project with two independent bottlenecks