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Serious reactions are extremely rare, especially when injections are performed by licensed medical professionals

However, both control animals as well as folate-deficient animals when treated with aspartame for 90 days, whether they were un-immunized or immunized, showed a marked increase in corticosteroid levels when compared to control as well as the folate-deficient animals

PMID: 17389505

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It makes it a popular ingredient in products targeting skin lightening and the treatment of conditions such as melasma and hyperpigmentation disorders

Muscle preservation: Because AOD 9604 targets adipose tissue specifically and does not suppress systemic anabolic signaling, researchers have hypothesized that it may allow for fat loss with less collateral impact on lean mass, though this has not been formally tested in head-to-head trials