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Although it is not exactly clear how GPx1 upregulation is affecting NMDA activity following kainic acid, exposure of GPx1 overexpressing neurons grown in culture caused an accumulation of GSSG in the media, compared to the effects of kainic acid on wildtype neurons
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Barton DL, Wos EJ, Qin R, et al

Supplementation of GSH was sufficient to restore the gene expression level close to that of the control cells, while inhibition of GGT severely impaired the rescue (Fig

Free Radic Res (2018) 52(5):592604

Elevated CO2 and reactive oxygen species in stomatal closure
