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Homocysteine interacts with various molecules produced from endothelial cells, including thrombomodulin and Von-Willebrand factor leading to disturbance of the endothelial coagulant/anticoagulant axis with the development of thrombosis (Nilsson et al

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In addition, zinc plays a vital role in the thyroid hormones metabolism by regulating thyrotropin-releasing hormone (TRH) and TSH synthesis and modulating the structures of essential transcription factors involved in synthesizing thyroid hormones (177, 178)

GH also activates the MAPK/ERK pathway through Shc recruitment, the PI3K/AKT/mTOR pathway through IRS adaptors, and Src family kinases through a JAK2-independent branch