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showed that MTX-induced liver, kidney and heart damage was ameliorated with a flavonoid derivative diosmin (Reference Abdel-Daim, Khalifa and Abushouk47)

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Far from being mere toxic byproducts of aerobic metabolism, ROS act as ubiquitous redox signaling mediators that regulate processes as diverse as cell proliferation, differentiation, inflammatory responses, autophagy and programmed cell death

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