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Then came the 2nd shot, after exactly 8 weeks, BAM

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The methodologic design of the rescue arm favors the sq methotrexate group, in that, on average, approximately 10% of the subjects in this group received a 25% higher dose of methotrexate than did those in the oral group (who could never receive a dose higher than 15 mg as part of the protocol)

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Advise patients that there is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to trazodone during pregnancy [see Use in Special Populations ( 8.1)]

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