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Masitinib is the first tyrosine kinase inhibitor in this class of agents that targets the innate immune system by inhibiting mast cell activity [310, 311], that may contribute to EAE and MS [312]

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Furthermore, elevated levels of markers for glial cells (GFAP and Sox-10) and multiple pro-inflammatory cytokines are found in colon biopsy samples from individuals suffering from PD (84, 172)

The majority of clinical investigations conducted thus far are characterized by limited sample sizes, abbreviated intervention periods, and diverse study designs, thereby complicating the establishment of optimal dosing regimens, timing of administration, and the effective combinations of these therapeutic modalities