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Jan 18, 2026 You've done the research
Split dosing at 0.25 mg twice daily (morning and evening) may provide more consistent peptide exposure throughout the day
Jorgensen and Huss, 1989
Stacked on top of insulin or a sulfonylurea it can, and the lever is de-intensifying that background drug, not lowering the tirzepatide dose. Over-loss in low-BMI deep responders Across the obesity trials, about 7% of participants fell below a BMI of 22, some by week 12
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Matern Child Nutr 2014;10:22633
