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Monocarboxylate transporters in the central nervous system: distribution, regulation and function

A fatty substance called Myelin is essential for the formation of these sheaths

Every breath we take and every bite of food we eat offers an opportunity for new, unrecognizable substances, pathogens, and toxins to enter the body, where they must be identified, assessed for toxicity, and finally metabolized

In addition, the extracellular ligand-binding domain of LRP2 binds to various large macromolecules, including lipoprotein lipase, apolipoproteins E and B, and albumin

However, clinical translation faces challenges, including pathway redundancy, off-target effects, and the need for precise dosing to balance protective and detrimental outcomes

Curr Neurol Neurosci Rep 13: 345 Commisso C, Davidson SM, SoydanerAzeloglu RG, Parker SJ, Kamphorst JJ, Hackett S, Grabocka E, Nofal M, Drebin JA, Thompson CB, Rabinowitz JD, Metallo CM, Vander Heiden MG, BarSagi D (2013) Macropinocytosis of protein is an amino acid supply route in Rastransformed cells