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These mediators are responsible for clinical symptoms such as nasal congestion, sneezing, itching, and/or rhinorrhea

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The behavioral outcomes (OFT, TST, FST) and cytokine shifts (TNF-, IL-1) are well-established and closely match the endpoints examined in our work

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Acknowledgements We thank the Canadian Institutes of Health Research for support of operating grant for our preclinical and clinical research on niacin

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