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doi:10.1371/journal.pone.0042357 7
SURMOUNT-MAINTAIN (Horn 2026, 112 weeks): continued top dose -21.9% vs 5 mg step-down -16.6% vs placebo -9.9%, rescue therapy 8/25/67%: Aronne JAMA 2024
Since the respiratory chain of mitochondria contains a large amount of molecular oxygen it is predisposed to radical generation
Specific disulfide linkage between homocysteine and the sulfhydryl group of an intracellular protein may be an alternative molecular mechanism underlying hyperhomocysteinemia-induced vascular dysfunction
C., Wu, Z., Geng, Y., & Moshage, H
Clinical practice suggests that acupuncture offers multi-target regulation, holistic effects, reliable efficacy, minimal side effects, and good patient compliance
