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In addition, at later stages of pluripotency, -KG derived from glutamine can promote early differentiation, suggesting that the stage of cellular maturity can alter the effect of -KG 105
A realistic goal is to reduce body weight by about 5% within the first 3 months
Additionally, the decrease in pyroglutamate at M12 as compared to M0, may indicate recovery of glutathione metabolism by introduction of E-HD
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doi: 10.1038/nm.2807 [DOI] [PMC free article] [PubMed] [Google Scholar] 32.Yao S, Zhou Z, Wang L, et al
