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Oxidative stress can disrupt these tolerance mechanisms by inducing apoptosis of regulatory T cells (Tregs), which are critical for maintaining immune homeostasis and preventing autoimmunity [141]

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These lingering symptoms can include fatigue, joint and muscle pain, cognitive difficulties, and neurological issues, often severely impacting quality of life

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At the 12 mg dose at 48 weeks: -24.2% mean body weight versus -2.1% placebo