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NAD + is mainly consumed in three ways, in which NA is produced, and 4 enzymes, sirtuins, ADP-ribosyl transferases (ARTs), poly-ADP-polymerases (PARPs), and cADP-ribose synthases, are involved (Figure 1)

45,46 Based on these findings, it can be concluded that S-amlodipine-induced liver inflammation and dysfunction are mediated by the gut microbiota