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Injection sites can be local (near injury) or systemic (abdominal or thigh)

Pan J, Zhu J, Li L et al (2023) Salidroside attenuates LPS-induced kidney injury through activation of SIRT1/Nrf2 pathway

10.1017/S0022029900030600

J Nutr 144, 1128S1136S

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Additionally, the neurogenic locus notch homolog protein 1 (NOTCH1) signalling pathway [133] and the phosphoinositide 3-kinase (PI3K)-protein kinase B (AKT) pathway [176, 177], have also been shown to augment NFE2L2 transcription, and consequently activate NRF2 signalling, thus maintaining redox balance