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Similarly, neither of these studies involved implanting the hydrogel into the load-bearing intervertebral discs of live animals to observe their performance over the long term ( Annulus Fibrosus Repair Patches: Borem et al

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In the obese state, increased levels of fatty acids and cytokines in circulation induce activation of inflammatory signalling pathways such as STAT3 (signal transducer and activator of transcription 3), p38 MAPK (p38 mitogen-activated protein kinases) and NFkB (nuclear factor kappa-light-chain-enhancer of activated B cells) in metabolic tissue 35,36