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Description
Phases I and II enzymes catalyze the conversion of a lipophilic, non-polar xenobiotic into a more water-soluble and therefore less toxic metabolite, which can then be more easily excreted from the body
Acta 137 OrreniusS.GogvadzeV.ZhivotovskyB
References Roeder, T., Seifert, M., Kahler, C
The primary hepatocytes were initially cultured in DMEM medium for 24 hours, after which the wells were washed once with PBS
HepG2 cells, transfected with human CYP2E1-expressing gene, (E47 cells) have been established to study CYP2E1-dependent ethanol hepatotoxicity [122, 22]
10.1038/nature22379
