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doi: 10.1038/s41598-025-12108-1 108 TangLWuJLiCGJiangHWXuMDuMet al

burgdorferi than in samples exposed to live bacteria, and several times higher in the frontal cortex than the dorsal root ganglion

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Systemic regulation of iron metabolism primarily occurs in the liver, where hepcidin binds to FPN, leading to its degradation and inhibition of iron export, thereby contributing to intracellular iron accumulation [99]