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Both delivery methods can cause reactions, but the mechanisms differ slightly

However, UGA can encode for selenocysteine using a stem-loop structure (known as the selenocysteine insertion sequence, or SECIS element), which is found at the 3 untranslated region of the mRNA

After treatment with CPP-CAND, a significant reduction of approximately 7.1-fold in the number of FOXO4 foci was observed in the nuclei of the senescent cells

These observations indicate that GSH-dependent thiol modifications regulate necroptosis at multiple hierarchical levels, from upstream checkpoint proteases to terminal membrane-disrupting effectors

for this reason, GSH is being investigated as a potential therapeutic method, as it is the main protective mechanism against elevated oxidative stress

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