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Most noninferiority trials were not designed to preserve active comparator treatment effects

Activated microglia, the immune cells of the brain, release inflammatory mediators that sensitize pain pathways

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For the primary efficacy analysis of actimetry and home diary outcomes, the outcome values were calculated using the measures performed during the planned weeks of assessment (the first and last week of each treatment period) without deviations from the target oral l-dopa dose (that is, a week when the patient did not receive the oral optimized l-dopa dose determined in phase 1 of the DIVE-1 study)

2021;12 doi: 10.3389/fphar.2021.661217

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