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The link between nicotine addiction and other substance use disorders is that nicotine addiction serves as a gateway to other substance use disorders, as individuals who are addicted to nicotine incur a higher susceptibility to alcohol and drug use

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So, how does all of this relate to nicotine addiction?

Siegel and Cahn note that effectiveness may not hinge on nicotine delivery: Taken together, this evidence suggests that electronic cigarettes are capable of reducing cigarette craving, but that the effect is not due exclusively to nicotine

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