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Through TULP1 knockout models in zebrafish, scientists found that TULP1 deficiency causes early-onset retinal degeneration through up-regulating ferroptosis-related genes, increasing the shrinkage of mitochondria, iron and lipid droplet deposition and reducing mitochondria cristae, and increasing the death of photoreceptors via ferroptosis (Jia et al., 2022)

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doi: 10.1158/0008-5472.CAN-18-3927 53

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