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Copper peptide serums demonstrate this principle effectively

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Teughels W, Durukan A, Ozcelik O, Pauwels M, Quirynen M, Haytac MC (2013) Clinical and microbiological effects of Lactobacillus reuteri probiotics in the treatment of chronic periodontitis: a randomized placebo-controlled study

Mel Gibson has reportedly credited it
Monitoring should be straightforward: subjective pain and function reporting at four weeks, basic labs if comorbidities warrant
Animal studies so far show a good safety profile