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Continuous use beyond 6 weeks leads to IGF-1 receptor downregulation (decreased density and sensitivity)
doi:10.1017/S0317167100034971
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Aesthetics: Neurotoxin for expression lines that are transitioning from dynamic to static
Stress & Increased Cortisol Chronic stress increases cortisol, which triggers excess oil production
[PubMed] [Google Scholar] 74
