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In addition, genetically engineered cells expressing specific proteins or antigens can be used to produce NVs with targeting or antigen delivery capabilities

Cancers (2022) 14(13):3059

This process leads to the activation of macrophages, the secretion of inflammatory factors, and ultimately, inflammation in cells such as Kupffer cells, as well as hepatocytes, which produce significant amounts of cytokine, particularly TNF- and IL-6 (Allam et al

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Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKK