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2022,23, 2717 8 of 16 buffering effect also extends to the potentially toxic acyl-groups, resulting either from poorly metabolized fatty acyls and from xenobiotics such as antibiotics conjugated with pivalic acid and valproate [ 44 ], or from inhibition of certain metabolic pathways for example propionic acid in propionic acidemia [ 45 ]

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LIPID PEROXIDATION Irrespective of ROS type, the first stage of ROS-mediated cellular damage is peroxidation of cellular membrane components, especially membrane lipids in the process, called lipid peroxidation (47, 48)

2 : 333337 Reynolds CF, Frank E, Kupfer DJ, Thase ME, Perel JM, Mazumdar S et al