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32,35,215 However, at relatively high doses, methotrexate is also known to trigger a pro-oxidant state which further contributes to the structural and functional alteration of critical cell components, for example, lipids, proteins and DNA

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This is where glutathione intervenes to influence that process

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From a therapeutic perspective, future efforts should focus on identifying and validating novel ferroptosis regulators, particularly those targeting non-canonical pathways

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