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Collectively, the mast cell clock mediates circadian regulation of plasma histamine levels at steady state, in part by controlling OCT3 expression, which can be modulated by stress

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Acetyl-L-carnitine exerts its activity by enhancing energy metabolism, protecting neurons and improving synaptic plasticity

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Despite these distinct modes of action, multi-omics integration revealed convergent perturbations across molecular layers in the brain, particularly affecting energy metabolism and cytoskeletal organization with more pronounced effects observed following PTU exposure