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Furthermore, toxicometabolomic studies have demonstrated the utility of zebrafish in assessing drug-induced renal injury

It is recommended that the genotype-based activity score of CYP2D6 is adjusted based on the use of inhibitors, with the specific adjustment for phenoconversion depending on the strength of the inhibitor (moderate or strong)[142,143]

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In: StatPearls

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However, as a molecule with close structural homology to insulin, IGF-1 elicits a variety of metabolic products in vitro and in vivo that are similar to insulin, which can cause edema primarily in the face and hands, mild weight gain, occasional dyspnea, bilateral jaw tenderness, arthralgias and myalgias, fatigue, tachycardia, flushing, orthostatic, and hypotension [57]