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The CHMP opinion and the Health Canada approval, landing in the same week, together illustrate an unusually dense regulatory period in rare oncology on both sides of the Atlantic, a moment when the patient communities served by these drugs are watching pipeline-to-access timelines compress

This retrograde signaling from mitochondria to nucleus increases expression of cytoprotective enzymes, helping cells cope with oxidative stress

mTOR in programmed cell death and its therapeutic implications

134 ReinemerP.PradeL.HofP.NeuefeindT.HuberR.ZettlR.et al (1996)

Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis

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